Q10 Boosts Energy, Nerves, Muscles & Metabolism

Monday, February 18, 2013
By: Byron J. Richards,
Board Certified Clinical Nutritionist

Coenzyme Q10 was the first anti-aging superstar nutrient, hitting the consumer market in the 1970s.  Q10’s promise to turn back the clock on aging cells set the stage for many of the modern day anti-aging approaches based on nutritional science.

Over the years Q10 has been put to extensive scientific testing for a variety of purposes. It has amassed 30 years of solid research in the field of cardiovascular health, and is supportive in such areas as blood pressure, cholesterol, triglycerides, arterial health, and heart health. My article, Coenzyme Q10, Statins, and Heart Health goes into greater detail on the cardiovascular topic.

More recently, Q10 has demonstrated a significant ability to help nerves and muscles. New science shows that in addition to its antioxidant role, Q10 also helps stabilize the key gene signal underlying inflammation, NF-kappaB Protein complex that controls DNA transcription and is involved with cellular responses to stress, cytokines, free radicals, UV radiation, oxidized LDL, and infections. . Collectively, these benefits will assist overall metabolism, including weight loss efforts.

This article summarizes Q10’s importance to your health, as well as brings you up to date on recent findings.

Within every cell are cellular engines called mitochondria Organelle found in cells that produce ATP or chemical energy. Also involved with cell signaling, cellular differentiation, cell death, cell growth, along with heme and steroid synthesis. . Your nerves, muscles, heart, liver, and immune system all need large amounts of energy to perform their healthy functions, and so have a lot of mitochondria Organelle found in cells that produce ATP or chemical energy. Also involved with cell signaling, cellular differentiation, cell death, cell growth, along with heme and steroid synthesis. . 

Your cell engines combine fuel (calories) with oxygen, and then use various nutrients in a multistep process to produce cellular energy, known as ATP.  Many nutrients assist in this function, including B vitamins, krebs cycle cofactors, magnesium, lipoic acid, acetyl-l-carnitine, and Q10.

Thus, Q10 is part of your energy-producing team.  It plays a very important role in the final steps of energy production, and cannot be replaced or compensated for by any other nutrient. If you have an adequate amount you make energy at a more optimal rate.  If you are lacking you simply cannot make energy at the optimal rate and instead will make free radicals in direct proportion to the lack of Q10.

Since energy is fundamental to everything else, a lack of Q10 contributes to the aging process in all systems in your body, especially internal cellular health and those body systems that rely heavily on energy production (heart, liver, brain, and muscles).

Q10 itself can be synthesized in your body from the amino acid Building blocks of peptides and protein and have multiple roles of function in life including muscle function, growth, detoxification and metabolic pathways, and neurotransmitter function. tyrosine. Its formation requires eight nutrients:  tetrahydrobiopterin, vitamins B6, C, B2, B12, folic acid, niacin, and pantothenic acid. Plants contain no Q10. Animal meats do have Q10 with the highest amounts found in red meat.

The need for Q10 rises dramatically under the influence of stress.  If you maintain a better state of natural balance, then you will need less Q10.  As your stress level rises Q10 is used up faster.  If a deficiency persists then free radical production can accelerate, which further aggravates the lack of Q10.  This is a nasty problem commonly experienced by individuals with fatigue and a trend of worsening health.

Common Q10 doses are in the 100 mg - 300 mg range for general health. More advanced health problems respond better to doses in the 600 mg - 1,200 mg range. Look for a dose that noticeably boosts your energy, mood, and stress tolerance –  that dose will vary depending on how you are doing and how your life is going.

Antioxidants are your body’s natural defense system against free radicals. Your cells need a certain amount of antioxidants on hand simply to cope with the number of free radicals that are produced during normal energy production. 

Q10 is part of your antioxidant team. When it helps make energy more efficiently it helps reduce free radical production caused by inefficient energy production. Since Q10 is fat soluble it is also known to accumulate in your cell membranes and protect the important fatty structures of your cells from free radical damage. 

Q10 also helps recycle and recharge vitamin E and vitamin C so that they can continue to work as antioxidants. It is very clear that antioxidants work best as a team, and Q10 is a key player.

When antioxidants run low free radical damage is increased. In turn, this speeds the aging process. Q10 has gained notoriety as a potent anti-aging nutrient because it helps both energy production and antioxidant defenses in a significant way.

It is now extremely clear to the scientific community that mitochondrial problems1 are involved with almost all conditions of nerve-related deterioration. Since Q10 is capable of helping correct mitochondrial dysfunction, it is a key nutrient to help slow and possibly reverse age-associated changes in nerve health. Q10 is being widely studied as a nerve-protecting nutrient2 in a variety of neurological problems.

A landmark study published in 2002 proved that 1,200 mg per day of Q10 could slow the progression of Parkinson’s disease3. In this study, doses of 300 mg, 600 mg and 1,200 mg of Q10 were tested in patients who were in the early stages of Parkinson’s, over a 16 month period. Those who took the lower doses showed a trend toward improvement, but that trend only became statistically significant in the group who took 1,200 mg per day.  At this time, no study shows that Q10 can change more advanced stages of Parkinson’s. 

Parkinson’s disease involves destruction of the dopamine producing cells4 primarily in the substantia nigra midbrain region. The fact that this disease primarily affects a particular region of the brain, as opposed to the brain in general, has focused research on differences in that brain region compared to others.

A neurotoxin called MPTP is known to induce Parkinson’s-like disease in humans, not affecting other areas of the brain. It works by specifically disrupting the function of Q105 in the substantia nigra midbrain region, resulting in the loss of dopamine-producing nerve cells. 

Recently, scientists proved for the first time that Q10 levels are low6 in the substantia nigra brain region of Parkinson’s patients, proving a clear nutrient deficiency in the key brain region associated with Parkinson’s.

In addition to the energy boosting, antioxidant properties of Q10, other research shows that Q10 modulates the key inflammatory gene switch, NF-kappaB Protein complex that controls DNA transcription and is involved with cellular responses to stress, cytokines, free radicals, UV radiation, oxidized LDL, and infections. 7, meaning that dopamine nerve cells will be more resistant to any kind of stress. The ability of Q108 to modulate NF-kappaB Protein complex that controls DNA transcription and is involved with cellular responses to stress, cytokines, free radicals, UV radiation, oxidized LDL, and infections. all around your body is another angle on the anti-aging properties of Q10, as inflammation is also a key theme of wear and tear and accelerated aging.

Muscles are big users of Q10. A prolonged lack of Q10 may contribute to or possibly be the cause of significantly impaired muscle function.

The ability to use your muscles and get a good energetic response in their performance is based in no small part on your mitochondria Organelle found in cells that produce ATP or chemical energy. Also involved with cell signaling, cellular differentiation, cell death, cell growth, along with heme and steroid synthesis. 9. In middle-age untrained men, 150 mg of Q10 per day was shown to increase their sense of energetic vigor10. A dose of 300 mg Q10 per day increased the ability of healthy people to perform strenuous exercise before reaching fatigue11 (100 mg was not enough to show a difference in this study). In a study with 10 patients who had documented genetic Q10/mitochondrial problems, 150 mg of Q10 each day for six months produced clinically measurable remarkable improvement in brain and muscle function12. 

In serious issues of muscular dystrophies13, 100 mg of Q10 per day for three months produced clinically significant improvement in physical performance. The authors, in retrospect, believed the Q10 dose should be higher and recommended indefinite treatment with Q10 for any individual with any type of muscular dystrophy.

The immune cells required for “house cleaning” in patients with fibromyalgia Chronic pain disorder characterized by wide spread pain. Research suggests that central nervous system pain processing signals are in a state of dysfunction causing abnormal signaling. , who have significant muscle aches and trouble exercising, have 40 percent less Q1014 in their cell membranes than healthy people.  A preliminary study showed self-reported improvement in fibromyalgia Chronic pain disorder characterized by wide spread pain. Research suggests that central nervous system pain processing signals are in a state of dysfunction causing abnormal signaling. symptoms15 in 64 percent of patients who took 200 mg of Q10 per day over a 12 week period.

In patients with chronic heart failure16 300 mg of Q10 per day strengthened the heart over a four week period, as did exercise. Q10 levels in the blood were elevated four times higher from the supplements, compared to the control group, and even higher when Q10 was combined with exercise (meaning exercise helps condition the use of Q10 – in other words, energy begets energy).

Due to its combination of increased energy production and improved antioxidant function, Q10 is one of the best nutrients to take while on an exercise program.  A 200 mg per day dose of Q10 has been shown to reduce free radical damage and boost time to exhaustion17  – Q10 levels during exercise directly related to oxygen utilization.  Another human study showed that 90 mg of Q10 boosted fat burning18 during exercise.

To really understand how Q10 boosts fat burning during exercise it helps to understand a bit about the subject of uncoupling proteins.  Human genome mapping has identified five primary metabolic uncoupling proteins (UCPs). A UCP disconnects normal cell-energy production and turns calories into 100 percent heat. In essence, this is a method of completely disposing of calories – a great way to lose weight if you can do it in a healthy way.

A well-known example of this is the metabolism of brown adipose tissue, or BAT. This type of fat tissue is totally different from the white adipose tissue that stores extra fat. It has many nerves flowing into it, as well as a blood supply, thus giving it a brownish color and its name. It is the only tissue in the body that contains UCP1.

UCP1 allows this tissue to turn a calorie into 100 percent heat. Normal cell energy production makes 35 percent heat and 65 percent energy in the form of ATP.  Activation of BAT is naturally stimulated by an individual’s need to adapt to a colder temperature; the hallmark of its activation is the shiver response.

BAT is also stimulated by nerves, especially adrenaline. Since the 1980s, nerve stimulation of BAT has been a favorite target of many weight loss strategies that employ ephedra, caffeine, stimulant drugs, or some other type of nerve stimulant. The idea is that by stimulating BAT, extra fat calories will be melted away in the form of heat production.

We now know that this type of weight loss strategy is risky and prone to relapse. There are serious cardiovascular and kidney side effects from this type of excess and ongoing nerve stimulation. Too much nerve stimulation to lose weight invariably results in yo-yo dieting once the stimulation is stopped.

However, a different uncoupling protein called UCP3, which is found in your muscles, can also dispose of calories as heat. The great news is that it does this without any cardiovascular or kidney side effects or induction of the yo-yo response! 

You can activate UCP3 by achieving better leptin control, by aerobic exercise19, by increasing overall antioxidant status20, and specifically by taking Q1021. Even walking 150 minutes a week can boost UCP3 activity in type 2 diabetic patients22.

This gives you another great tool to help speed up the clearance of fat. Take some Q10, do some aerobic exercise, and you will tend to notice a better metabolic and fat burning response.

Q10 is an important nutrient to assist energy production and your antioxidant defense system. It helps your nerve, cardiovascular, and muscle health; and metabolism. Along with other factors that comprise a healthy lifestyle, Q10 is a terrific nutrient to have on your anti-aging team.

Read More:  Anti-Aging News, Antioxidants News, Cardiovascular Health News, Cholesterol News, Circulation News, Energy/ Fatigue News, Muscle Health News, Weight Management News
Tags: anti-aging, metabolism, muscles, nerve health, Parkinson's disease, Q 10, weight loss,
Referenced Studies: ^ Q10 for General Nerve Protection  Ann N Y Acad Sci.  Chaturvedi RK, Beal MF. ^ Q10 May Help Nerve Diseases  Free Radic Res.  Beal MF.  ^ Q10 Slows Progression of Parkinson’s Disease  Arch Neurol.  Shults CW, Oakes D, Kieburtz K, Beal MF, Haas R, Plumb S, Juncos JL, Nutt J, Shoulson I, Carter J, Kompoliti K, Perlmutter JS, Reich S, Stern M, Watts RL, Kurlan R, Molho E, Harrison M, Lew M; Parkinson Study Group.. ^ Q10, Mitochondria, and Parkinson’s  Biol Signals Recept   Ebadi M, Govitrapong P, Sharma S, Muralikrishnan D, Shavali S, Pellett L, Schafer R, Albano C, Eken J.  ^ Q10 Protects Dopamine Nerve Cells from Toxins  Brain Res   Beal MF, Matthews RT, Tieleman A, Shults CW ^ Q10 Low In Brain Region of Parkinson’s Patients  Neurosci Lett.   Hargreaves IP, Lane A, Sleiman PM. ^ Q10 Reduces NF-kappaB in Dopamine Neurons   J Mol Neurosci.   Kooncumchoo P, Sharma S, Porter J, Govitrapong P, Ebadi M. ^ Q10 Lowers NF-kappaB to Reduce Inflammation  Biofactors  Schmelzer C, Lindner I, Rimbach G, Niklowitz P, Menke T, Döring F. ^ Exercise Intolerance and Mitochondria  Ital J Neurol Sci   DiMauro S.  ^ Q10 Improves Subjective Sense of Vigor in Exercising Men  Int J Sports Med   Porter DA, Costill DL, Zachwieja JJ, Krzeminski K, Fink WJ, Wagner E, Folkers K.  ^ Q10 Enhances Exertion Time Before Fatigue Sets In  Nutrition.   Mizuno K, Tanaka M, Nozaki S, Mizuma H, Ataka S, Tahara T, Sugino T, Shirai T, Kajimoto Y, Kuratsune H, Kajimoto O, Watanabe Y. ^ Q10 Improves Muscle and Brain Function  Biofactors  Barbiroli B, Iotti S, Lodi R.  ^ Q10 Helps Muscular Dystrophy  Biochim Biophys Acta   Folkers K, Simonsen R.  ^ Q10 Lacking in Immune Cells in Fibromyalgia Patients  Clin Biochem.  Cordero MD, Moreno-Fernández AM, Demiguel M, Bonal P, Campa F, Jiménez-Jiménez LM, Ruiz-Losada A, Sánchez-Domínguez B, Sánchez Alcázar JA, Salviati L, Navas P. ^ Q10 Helps Improve Symptoms of Fibromyalgia  J Int Med Res   Lister RE.  ^ Q10 Helps Heart Failure Patients  Eur Heart J.   Belardinelli R, Muçaj A, Lacalaprice F, Solenghi M, Seddaiu G, Principi F, Tiano L, Littarru GP. ^ Q10 Enhances Exercise and Fat Burning  J Nutr Sci Vitaminol (Tokyo).   Zheng A, Moritani T. ^ How Q10 Helps Exercise  J Int Soc Sports Nutr.  Cooke M, Iosia M, Buford T, Shelmadine B, Hudson G, Kerksick C, Rasmussen C, Greenwood M, Leutholtz B, Willoughby D, Kreider R. ^ Aerobic Exercise Activates UPC3  Am J Physiol Endocrinol Metab.  Zhou M, Lin BZ, Coughlin S, Vallega G, Pilch PF. ^ Q10 and Antioxidants Boost Uncoupling Protein 3  Free Radic Biol Med.  Hellsten Y, Nielsen JJ, Lykkesfeldt J, Bruhn M, Silveira L, Pilegaard H, Bangsbo J. ^ Q10 Activates Uncoupling Proteins  Proc Natl Acad Sci U S A.   Echtay KS, Winkler E, Frischmuth K, Klingenberg M. ^ Walking Helps Uncoupling Protein 3 in Diabetic Patients  Diabetes Metab Res Rev.  Fritz T, Krämer DK, Karlsson HK, Galuska D, Engfeldt P, Zierath JR, Krook A.

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How Protein Helps Weight Loss

Thursday, April 18, 2013
By: Byron J. Richards,
Board Certified Clinical Nutritionist

The amount of quality protein in your diet is the single most important calorie that influences your metabolic rate, favorably influencing weight loss. Quality protein also helps you sustain muscle during weight loss, improve muscle fitness, immunity, and antioxidant function, build HDL Cholesterol High-density lipoprotein that is one of five lipoproteins that enable cholesterol and triglycerides to be transported within the bloodstream to the liver and to the adrenals, ovaries, or testes for the production of steroid hormones. , and enhance insulin and leptin function – all of which contribute toward optimal weight management efforts over time.

A significant body of scientific evidence indicates that protein levels far higher than our government’s suggested levels of intake are optimal for weight loss1, as long as you simultaneously decrease carbohydrate intake. A minimal target amount is three-fourths of your ideal body weight in grams of protein per day, ranging up to three-fourths of your actual weight in grams of protein per day.

For example, if you should weigh 160 pounds but you currently weigh 200 pounds, then your goal for protein intake is in the range of 120 to 150 grams of protein per day. Since each gram of protein is four calories, this means 480 to 600 calories per day from protein. This is around 30 percent of your calories from protein (based on a 2,000 calorie diet). 

The FDA says you need 50 grams of protein per day (200 calories), based on a 2,000 calorie diet, or 10 percent of your calories from protein. The FDA bases its guidelines on only one aspect of protein need, nitrogen balance.  Nitrogen, found only in protein, is a fundamental molecule required for building body structure and DNA synthesis. 

The FDA’s goal is to make sure you have enough dietary protein so you don’t wither away. That’s nice, but nitrogen balance as the only criteria for protein intake ignores the role of protein as a signaling molecule2 in metabolism, especially in regard to how your muscles function. It ignores the amount of protein needed to preserve muscle during weight loss and facilitate fat burning.  In fact, the FDA gives no guidelines to explain how much quality protein you need for exercise, stress, blood sugar3 support, or to help stabilize muscle and blood sugar as you age4. 

The simple fact of the matter is: when you increase quality protein intake over the basic amount needed for nitrogen balance, then the branch chain amino acids like leucine, which are metabolized in your muscles (not in your liver as are other amino acids), directly and favorably benefit muscle function and health – including enhanced calorie burning by muscle that clearly supports healthy weight loss5.

The FDA also thinks you should have only 65 grams of fat (585 calories or 29 percent of your calories). Of this fat, the FDA wants to make sure you eat very little satisfying and energy producing saturated fat (20 grams, 180 calories), preferring that you get most of your fat from cholesterol-free, inflammation generating vegetable oils. You are supposed to round out this diet with 300 grams in carbohydrates (1200 calories), 60 percent of your calories. 

Attempting to follow FDA guidelines is a fast track to obesity, as you end up eating more food because this ratio of calories causes you to feel unsatisfied, thus you eat more trying to feel full.  Not only that, but new research also shows that eating this way damages your leptin controlled, appetite regulation center in your subconscious brain, literally killing important brain cells, so that you no longer properly get a full signal. 

My recommendations for weight loss, based on helping thousands of people lose weight, is to consume 30 percent protein (600 calories), 30 percent carbohydrates (600 calories), and 40 percent fat (800 calories). Do not snack and do not eat after dinner at night. Eat either two or three meals a day. 

The idea of a 2,000 calorie diet is for food labeling purposes.  Women may need 500 fewer calories and men may need slightly more, but the ratios should stay the same. The heavier your ideal weight and the more active you are, the more calories you can consume. Many Americans are eating 3,000 to 4,000 calories a day, often twice what they actually need. On top of that, a lot of the calories consumed are poor quality junk, adding insult to injury. 

When you reach an ideal weight you can gradually increase carbohydrates to 40 percent – even 50 percent if you are very active. If you are quite active then leave protein at 30 percent, and cut back on fat, if desired. If you are not highly active, yet are at an ideal weight, then eat 25 percent protein, 40 percent carbohydrates, and 35 percent fat.

On any diet, eat half your fat grams in saturated fat or you will not feel satisfied and you will have trouble sustaining energy between meals, which will cause you to be tired and eat more carbohydrates. Get two to six grams of omega-3 essential fatty acids per day (higher amounts for weight loss and cardio health), and try to consume most of the rest of your fat as omega-9 monounsaturated fat (like olive oil). 

These are the calorie basics for weight loss and weight maintenance. The following information explains why this works.

Protein is made up of various amino acids. In terms of weight loss, scientists are finding that the most important amino acids are the branch chain amino acids, especially leucine. If you get your protein intake high enough, especially in proteins that are rich in leucine, a number of very interesting things happen that can activate a sluggish metabolism and result in weight loss.

One easy way to get a lot of leucine, without any fat, is to use high quality whey protein. Casein, a common dairy protein allergen, is not part of whey protein.  The finest whey proteins use advanced filtration technology to leave all the protein molecules intact. In this process saturated fat, cholesterol, and lactose are removed, yielding a very useful leucine rich food for metabolic enhancement.

The highest sources of leucine containing foods are animal and dairy.  Cottage cheese and red meat top the list; other sources include milk, cheese, eggs, pork, fish, chicken, legumes, peanuts, nuts, and seeds. If you avoid red meat and dairy products, it is harder to get leucine containing foods in higher amounts, though not impossible. Using whey protein makes it easy.  I always recommend individuals stay away from processed soy protein (like soy protein drinks), as it is anti-thyroid in higher amounts.

Eating two eggs for breakfast has been shown to boost weight loss by 65 percent, compared to the same amount of calories from carbohydrates, like a bagel.

One of the key researchers in this area, Donald Layman, Ph.D.6, from the University of Illinois, has published many papers on the subject.  He has found that the high protein, leucine rich diet, in combination with lower carbohydrates (150 grams or 600 calories per day) is effective to support weight loss, blood sugar metabolism, and a variety of factors that have an impact on cardiovascular health.

His research points out that during weight loss our bodies can easily lose muscle mass (and bone for that matter). Leucine has a direct signaling effect on muscle that prevents muscle loss during weight loss. This means that on a high protein diet, the weight that is lost is mostly fat, not muscle. Whereas on a high carbohydrate weight loss diet, much more muscle is lost.

Leucine directly communicates to insulin, instructing it to work efficiently in muscle. This not only helps preserve muscle mass, but also helps muscles use glucose as fuel, in turn supporting healthy insulin function.

This high protein, leucine rich diet invariably lowers blood levels of triglycerides, which helps leptin7 get into your brain easier so that you feel full on fewer calories.  Once leptin gets into your brain correctly, leptin resistance8 is reduced, and your metabolism gets a go signal.  Whey protein is especially helpful in improving your brain’s feeling of food satisfaction9.  Many bioactive peptides in whey regulate appetite, a benefit attainable only from consuming whey protein10 in higher amounts.

The important HDL Cholesterol High-density lipoprotein that is one of five lipoproteins that enable cholesterol and triglycerides to be transported within the bloodstream to the liver and to the adrenals, ovaries, or testes for the production of steroid hormones. needs adequate dietary protein in order to form its structure.  We now know that HDL proteins get “spent” as HDL works to help clear LDL cholesterol Low-density lipoprotein. It is a group of lipids and proteins that allow lipids like cholesterol, triglycerides, and fat soluble nutrients (Vitamin A, D, E , K, Q 10, carotenes) to be transported with the water-based bloodstream. .  If you don’t have adequate protein you can’t make quality HDL at an optimal rate. A higher protein diet supports HDL formation while lowering triglycerides, a two-pronged benefit that not only helps weight management but also supports a healthier lipid profile for cardiovascular well-being.

Layman points out that having a high protein breakfast11 is needed to maximize these benefits of protein, which is consistent with rule #4 of the Leptin Diet: Eat a breakfast containing protein. 

In order to benefit from high protein for weight loss, the amount of carbohydrates must be reduced, which is rule #5 of the Leptin Diet®: Reduce the amount of carbohydrates eaten. This is because carbohydrates are easy-to-use fuels.  When you eat less, you encourage your body to break down stored fat. You prevent your body from converting muscle protein to fuel (blood sugar) by eating higher protein, thus preserving muscle mass.

Another great reason to eat a high protein breakfast is that it wakes up your liver and gives it something to do.  Your liver is the metabolic factory of your body. A high protein breakfast can increase your metabolic rate by 30 percent for as long as 12 hours, the calorie burning equivalent of a three to five mile jog. Fats and carbohydrates are easy for your liver to use, increasing liver metabolism by only four percent, whereas protein must be taken apart and reassembled for use elsewhere in your body. This dynamic effect of protein has recently been shown to be the key in supporting your natural ability to burn fat at a faster rate12 when consuming a diet higher in protein.

All your body structures, many hormones, a lot of enzymes, and neurotransmitters all require special proteins that your liver must help make. Protein showing up at your liver is like 2-by-4-inch lumber and plywood showing up at a home construction job site.  If it isn’t there, not much will get done.

A higher protein diet also has a natural diuretic effect. Individuals with extra weight are often sluggish, and hold extra water. This not only makes their blood pressure go up, as their heart tries to push harder to move the stagnation, but the extra water in connective tissues also gets directly in the way of fat burning. When you eat a higher protein diet then an important blood protein called albumin will increase. As albumin increases, through osmotic force, it draws water back out of your connective tissues, thus helping you get rid of fluid retention. If you have too much inflammation13, then your kidneys may leak albumin into your urine, provoking fluid retention, weight problems, and significant cardiovascular risk.

A major problem of lower protein diets is just the opposite – the more carbohydrates overweight people eat, the more fluids they retain.  Further, higher carbohydrate meals stimulate too much leptin production, in turn provoking leptin resistance and inappropriate desire for more carbohydrates.  Too many carbohydrates cause your willpower to be in a constant wrestling match with out-of-balance leptin.  It is rather obvious from the amount of yo-yo dieting in our society that misguided leptin usually wins.  The best way to win the wrestling match is to not have it in the first place, meaning eat fewer carbohydrates.

When weight is lost on a higher carbohydrate diet it is much more likely that people will hit a plateau in a few months that they cannot get past, long before the goal weight is reached.  Successful ongoing weight loss is much easier, and much less prone to stubborn plateaus, when your basic diet is higher in quality protein.

One reason unrelated to weight loss that I really like whey protein is that it helps your body make its most important antioxidant and immune support compound, glutathione.  Forty-five grams of whey protein per day has been shown to boost glutathione levels14 in immune cells by 24 percent over a two week period of intake, whereas 15 grams per day was not effective.  Further, many molecular weights of the proteins are in the immunoglobulin range15, meaning that your body can easily use them, if needed, to mount a more effective immune response.  Leucine, as a key signal for DNA protein synthesis, is important to the rate at which your body can manufacture immune cells16 in a time of need.

Whey protein has been extensively tested as an enhancement to athletic performance17, and has been shown to help build strength18. 

Polycystic ovary syndrome (PCOS) is a female insulin-resistance and leptin driven endocrine problem that results in obesity, facial hair growth, and acne. Researchers compared a lower calorie diet fortified with 60 grams of whey protein19 compared to 60 grams of carbohydrates. After a two month program the whey protein group lost on average six more pounds of fat, while dropping total cholesterol by 33 more points, compared to the carbohydrate group.

Another study of 95 men and 32 women used a 15 gram whey protein meal replacement for two meals a day for six months, and then switched to one meal replacement per day for six more months. While this amount of whey protein is significantly below what I would recommend to assist weight loss, the results of the trial were still quite good. During the first six months participants lost 20 pounds20 on average. In the next six months, on only 15 grams of whey protein per day, they kept their weight off and lost another two pounds. Further, many key parameters of cardiovascular health and leptin fitness were improved during the study, including decreases in total cholesterol, LDL cholesterol Low-density lipoprotein. It is a group of lipids and proteins that allow lipids like cholesterol, triglycerides, and fat soluble nutrients (Vitamin A, D, E , K, Q 10, carotenes) to be transported with the water-based bloodstream. , triglycerides, glucose, insulin, and systolic and diastolic blood pressure, while HDL Cholesterol High-density lipoprotein that is one of five lipoproteins that enable cholesterol and triglycerides to be transported within the bloodstream to the liver and to the adrenals, ovaries, or testes for the production of steroid hormones. increased.

Many people involved alternative health are under the false impression that a high protein diet is acid forming, and thus bad for bones.  Whey protein is actually good for bones21.  Forty grams of whey protein per day for six months increased bone mineral density in young women22 by a statistically significant 1.57 percent, and in postmenopausal women by a statistically significant 1.21 percent.  Plenty of fresh fruits and vegetables, along with a higher protein diet, is never bad for bones.  In fact, research shows that low protein24 leads to bone loss.  Fruits and vegetables provide the alkaline mineral buffers so that protein can work in a healthy way, including the support of bone growth.  Protecting against bone loss during weight loss is very important; whey protein is an excellent food to have in your corner.

It is true that some people have lost muscle mass, are inactive, and may have significantly compromised health to the point they have some difficulty metabolizing higher amounts of protein (they tend to have difficulty eating almost anything). If you fall into this category, the way to metabolize more protein is to gradually increase your intake while you simultaneously improve your fitness. As you build strength, you will be far healthier, your pH will be better, and you will be able to get the benefits of eating a higher protein diet; for most people, it is simply a matter of increasing protein and reducing carbohydrates. 

Higher amounts of high quality, leucine rich protein are needed for fitness, healthy weight loss, and to maintain weight following a weight loss program. This is one of many important strategies to improve the function of leptin in your metabolism, which is the key to successful weight loss and keeping the weight off once you have lost it.

Originally published 12/15/08.

Referenced Studies: ^ High Protein as an Effective Tool for Weight Management  Am J Clin Nutr.   Paddon-Jones D, Westman E, Mattes RD, Wolfe RR, Astrup A, Westerterp-Plantenga M. ^ Leucine Signals Muscles to Build and Repair  J Nutr.  Michael J. Rennie, Julien Bohé, Ken Smith, Henning Wackerhage and Paul Greenhaff. ^ Protein Helps Blood Sugar Regulation  J Nutr.   Layman DK, Baum JI. ^ Protein, Leucine, and Aging  J. Nutr.   Satoshi Fujita and Elena Volpi. ^ Higher Protein Boosts Muscle Metabolism and Weight Loss  J Am Coll Nutr.   Layman DK. ^ Leucine Unlocks Metabolic Door  J Nutr.   Layman DK, Walker DA. ^ High Protein Diets IMprove Your Brain’s Leptin Function  Am J Clin Nutr.  Weigle DS, Breen PA, Matthys CC, Callahan HS, Meeuws KE, Burden VR, Purnell JQ. ^ Whey Protein Improves Leptin and Insulin Function  Br J Nutr.   Pichon L, Potier M, Tome D, Mikogami T, Laplaize B, Martin-Rouas C, Fromentin G. ^ Whey Protein Reduces Appetite  Burton-Freeman BM.  Glycomacropeptide (GMP) is not critical to whey-induced satiety, but may have a unique role in energy intake regulation through cholecystokinin (CCK). ^ High Whey Protein Intake Reduces Appetite   J Am Coll Nutr.   Luhovyy BL, Akhavan T, Anderson GH. ^ Higher Protein Boosts Muscle Metabolism and Weight Loss  J Am Coll Nutr.   Layman DK. ^ Higher Protein Boosts Fat Burning  Nutrition & Dietetics  Marijka BATTERHAM, Rachael CAVANAGH, Arthur JENKINS, Linda TAPSELL, Guy PLASQUI and Peter CLIFTON.  ^ Albumin, Fluid Retention, and Cardiovascular Risk   J Clin Hypertens (Greenwich).   Bakris GL. ^ Whey Boosts Production of Key Glutathione Antioxidant  Int J Food Sci Nutr.  Zavorsky GS, Kubow S, Grey V, Riverin V, Lands LC. ^ Whey Protein for General Immune Support  Br J Nutr.   Pérez-Cano FJ, Marín-Gallén S, Castell M, Rodríguez-Palmero M, Rivero M, Franch A, Castellote C. ^ Leucine Helps Immunity  J. Nutr.  Phillip C. Calder. ^ Whey Protein Isolate Boosts Strength and Body Composition  Curr Opin Clin Nutr Metab Care.  Hayes A, Cribb PJ. ^ Whey Protein Improves Stength from Exercise Training  Int J Sport Nutr Exerc Metab.   Cribb PJ, Williams AD, Carey MF, Hayes A. ^ Whey Protein Helps PCOS   Fertil Steril.  Kasim-Karakas SE, Almario RU, Cunningham W. ^ Modest Whey Protein Intake Supports Weight Loss  Am J Clin Nutr.   Keogh JB, Clifton P. ^ Whey Protein Helps Bones  Br J Nutr.   Kruger MC, Plimmer GG, Schollum LM, Haggarty N, Ram S, Palmano K ^ Whey Protein Helps Young Women Improve Bone Density  Osteoporos Int.   Uenishi K, Ishida H, Toba Y, Aoe S, Itabashi A, Takada Y. ^ Whey Protein Helps Postmenopausal Women Build New Bone  Osteoporos Int.   Aoe S, Koyama T, Toba Y, Itabashi A, Takada Y. ^ High Protein Diets Help Bones, Low Protein Diets Harm Bones   Eur J Nutr.  Tucker KL, Hannan MT, Kiel DP.

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Combat Spring Congestion and Sluggishness Naturally

Friday, May 31, 2013
By: Byron J. Richards,
Board Certified Clinical Nutritionist

During the past few weeks of spring, much of the country has seen quite a lot of rain. These wet conditions combined with leftover autumn leaves create higher levels of mold spores in the air, posing an immune system stressor for many people. You may notice more mental fogginess, irritability, lower energy, or congestion.

Mold spores enter the air and travel on water molecules directly into your sinuses, causing stuffiness. Such mold spores are not infectious in and of themselves. They are, however, cousins of Candida albicans. While dampness-related stress is not an issue for many people, it is for others. Those more likely to notice the issue have a history of Candida imbalance, are prone to sinus congestion in general, are sensitive to molds, hate the smell of a damp basement, etc.

In addition to mold, temperature fluctuations and pollen further aggravate the immune stress that many people experience in spring, putting pressure on optimal immune function. Every time a protective barrier surface of your body is challenged, it initiates an immune response to help resolve the issue. This is simply your immune system carrying out its natural and normal function. However, the more sneezing that is involved, the greater the irritation and histamine release. Like emotional stress, it’s just one more thing for your immune system to deal with.

To have optimal immune function available to deal with other issues, it is best to have clear sinuses as a baseline of healthy function. Clear sinuses also reflect better overall lymphatic function, as described in my article A Healthy Lymph System is Vital for Flu Fighting Immunity.

While this issue begins as sinus stuffiness and pressure, it can develop into extra sinus mucus and a drop in energy. It often leads to cravings for sugar – another factor that is highly stressful to healthy immune function.

The moral of the story is to do what you can to keep your sinuses clear during damper spring weather. Many nutrients can help. Plant extracts like oregano oil1 and noni offer popular nutritional support for sinus health. Quercetin helps stabilize immune cells that line your sinuses, helping your body cope with this type of stress. Arabinogalactan3 is a popular lymph support compound that assists with the sensation of pressure build up.

Just as you must eat well and get adequate sleep for optimal immune function, you also want to minimize any form of stress. Sinus stress is just one on a long list of possible stressors, but it is crucial for many people this time of year.

Read More:  Immune Health News, Respiratory Health News, Sinus Health News
Tags: fall, Immune Plus, Lymphatic function, mold, Monolaurin, Noni, Oregano Oil, Quercetin, sinus, Vitamin C,
Referenced Studies:

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Quercetin, Skin Issues, and Stress

Friday, January 18, 2013
By: Byron J. Richards,
Board Certified Clinical Nutritionist

Quercetin has been found to powerfully stabilize mast cells1, helping prevent stress-induced anxiety and allergic reactions. A chain of recent discoveries helps place the significance of these discoveries in context, with far ranging implications for human health, and improved nerve tolerance for managing stress.

One study shows that stress2 itself is adequate to begin the migration of immune cells toward your skin, as if preparing to deal with a wound or infection – clearly an evolutionary strategy wherein stress typically implied injury of some type. Another new study shows that stress turns up the volume on mast cells3, priming them to release inflammatory chemicals that are typically involved with allergies, asthma, skin conditions, and digestive problems. Furthermore, the communication coming from mast cells feeds back to nerves, and modulates behavior through a sense of anxiety. Mice that are bred with no mast cells have no fear; they boldly venture out and are easy prey.

Additionally, irritants besides stress can also activate immune cells, causing skin problems or other allergy reactions on mucosal surfaces (like your lungs or sinuses). A case in point is an overgrowth of Candida in your digestive tract, whose allergic by-products are now associated with asthma and skin problems. Such issues invariably involve excessive mast cell activation. 

This data paints a clear picture that stress, behavior, skin problems, and other allergy issues are linked with mast cells as modulators. Problems occur when the mast cells are primed and set in an overreactive mode. This means that a common stimulus, such as a moderate amount of stress, could trigger anxiety, allergic reactions, sneezing, or in more advanced situations could lock in chronic skin or breathing problems.

A natural way to help stabilize mast cells can help them calm down and behave more appropriately, rather than having a subconscious saber-tooth tiger at the door. While many nutrients found typically in fresh fruits and vegetables are likely to help, quercetin stands out as the top nutrient to help stabilize mast cells. Of course, reducing the trigger that is punching mast cells in the nose, such as stress or Candida, will also help.

One study with mice showed that pretreating them with quercetin prevented the anxiety response4 to experimental stress via mast cell stabilization. The researchers found that quercetin was highly protective to the nervous system. The dose used translates to 1,500 mg – 3,000 mg per day for a 150 pound adult. Quercetin not only prevents mast cells from inappropriately releasing irritant chemicals5 like histamine, but it also reduces the inflammatory6 immune system signals like IL-6 that come from mast cells and are known to talk to nerve cells (glial cells).

It is also worth noting that quercetin helps improve the overall efficiency of your immune response to combat infection. One recent study showed that quercetin simultaneously offset the effects of stress while it reduced susceptibility to the flu. 

Quercetin has a stabilizing effect of your nervous system and immune system primarily by modulating mast cell function. It is an effective nutrient for any person prone to allergy issues, sinus problems, breathing problems, skin problems, or digestive problems – especially when stress aggravates these issues.

Read More:  Allergies News, Candida News, Immune Health News, Sinus Health News, Skin Health News, Stress News
Tags: allergies, breathing problems, nervous system, Quercetin, sinus,
Referenced Studies: ^ Quercetin Stabilizes Mast Cells   J Biol Regul Homeost Agents.  Shaik YB, Castellani ML, Perrella A, Conti F, Salini V, Tete S, Madhappan B, Vecchiet J, De Lutiis MA, Caraffa A, Cerulli G. ^ Stress Activates Immune Cells in Skin  Am J Pathol,   Joachim RA, Handjiski B, Blois SM, Hagen E, Paus R, Arck PC. ^ Stress Activates Mast Cells  Science  Donald Pfaff, et al. ^ Quercetin Protects Against Stress  Journal of Medicinal Food.  Anil Kumar, Richa Goyal ^ Quercetin Is A Powerful Regulator of Mast Cells  Clin Exp Allergy.  Lee JH, Kim JW, Ko NY, Mun SH, Kim DK, Kim JD, Kim HS, Lee KR, Kim YK, Radinger M, Her E, Choi WS. ^ Quercetin Prevents Inflammatory Signal Release from Mast Cells  Br J Pharmacol.  Kandere-Grzybowska K, Kempuraj D, Cao J, Cetrulo CL, Theoharides TC.

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Grape Seed Extract’s Powerful Cardio Protection

Monday, February 04, 2013
By: Byron J. Richards,
Board Certified Clinical Nutritionist

Red grape seed extracts (GSE) are a powerful cardioprotective compound.  They strengthen your arteries/capillaries, and offer rather dramatic antioxidant protection for your arteries and heart. Also, through a number of mechanisms they reduce the likelihood that plaque will form in your arteries. 

New molecular science shows that the effects of GSE are much more diverse than previously understood.  GSE works actively at the gene transcription level to promote changes favorable to cardiovascular health that include reducing inflammation and improving cholesterol and triglycerides metabolism.  They have even been found to have natural germ regulating properties and are a potent anti-candida compound. 

A great deal of grape research has been spurred on by what is known as the French Paradox, a diet in which people consume higher saturated fats but with far less heart disease.  Red wine has been actively researched, since 1936 by Professor Jacques Masquelierin, in effort to explain why it may be protective. Contemporary research has validated, explained, and expanded on the earlier findings.  For example, in 2006 researchers pinpointed that compounds in red wine relaxed your circulation and that these compounds were highest in red wines from southwestern France and Sardinia, regions that are associated with increased longevity1.  In 2004 researchers found that postmenopausal women who consumed red wine absorbed less fat2 from a meal (compared to those who drank water).  So by all means, have red wine in moderation with your largest meal of the day, as desired. 

Polyphenols are a broad group of substances found in all plants.  Flavonoids are one type of polyphenol, among thousands of different flavonoids Plant compound that is associated with pigmentation. Flavonoids have been shown to modify allergens, viruses, inflammation, and various carcinogens. Found in green tea, citrus, berries, onions, parsley, red wine, dark chocolate, and others..  Red grapes are a rich source of a type of flavonoid called a proanthocyanidin.  Other common foods that contain some proanthocyanidins are apples, cinnamon, cocoa, cranberry, green tea, and black tea.  White grapes contain proanthocyanidins, but many less than red grapes.  All parts of red grapes contain some proanthocyanidins, including the juice, skins and seeds. 

Without any question, the highest source of small molecule and highly bioactive proanthocyanidins are found in red grape seeds.  The research in this report is based on the use of GSE.  Please do not be confused and think this research translates to products made from white grapes or with grape skins, or even red wine.  It is obvious that having any proanthocyanidins in your diet, regardless of their source, is beneficial to your health.  However, when you are looking to use a nutritional product to support your health you want standardization of the highly bioactive compounds that have been proven to assist health.  Even within GSE products there is variation in quality, just as various red wines have more proanthocyanidins than others. 

It is a favorite ploy of misleading marketers of white grape products and lower quality red grape products to quote red grape seed extract research, since the research on their compounds is lacking and inferior.  For the purpose of dietary supplements, only red grape seed extracts have the overwhelming science behind them. 

One more common confusion people have relates to ORAC value (ORAC= Oxygen Radical Absorbance Capacity).  ORAC is a way to measure the antioxidant activity of any substance for one type of free radical (peroxyl free radical).  It is fine if a product has a high ORAC value, but ORAC values are an indirect and imperfect measurement that have not been proven to be associated with any health benefit.  ORAC fails to miss the value of many compounds to quench the wide variety of free radical types and it does not begin to evaluate how a nutrient works in your body.  While red wine has a significantly higher ORAC value than white wine, many compounds can test high in ORAC value and not even hold a candle to what grape seed extracts actually do to assist your health.  I bring this up because higher ORAC values in no way mean a better product.  These ORAC values are being used by various product manufacturers and network marketing companies to mislead the public on the value of a given nutritional compound, implying superiority based on an ORAC score. 

The tested science behind a specific nutritional compound helps you predict how it may be able to help your health.  The science I review in this report is specifically on red grape seed extracts (GSE).

It has long been understood that GSE offers potent vascular protection.  Early on this was attributed to high caliber antioxidant mechanisms that guarded against plaque accumulation in the walls of your arteries.  GSE also attaches itself to collagen and can significantly strengthen collagen if it is weakened.  This aspect of GSE helps the integrity of the structure of your collagen rich vascular system.  In clinical practice it is one of the best nutrients to prevent bruising and breaking capillaries, including spider veins.  The new science explains that GSE works in many ways to support cardiovascular well-being.

One way that GSE assists your cardiovascular system is by helping your arteries relax3 so that blood can flow easier.  Through a mechanism of gene transcription4 GSE helps turn on the important enzyme known as nitric oxide synthase, which produces the friendly nitric oxide (eNOS Endothelial Nitric Oxide Synthase. Type of enzyme involved with various physiological signals and maintenance activities with nitric oxide. ) that is required for the proper relaxed tone of your circulatory system and the smooth regulation of your blood pressure.

Another kind of nitric oxide (iNOS Inducible Nitric Oxide Synthase. This enzyme influences genes located in the neuro-immune and cardiovascular system and provides immune defense against pathogens and contributes to disease progression including neurogenic inflammation (iNOS2). ) is induced from different kinds of stress, such as chemical exposure, which is highly inflammatory in nature and damaging to your cardiovascular system.  GSE has a unique talent.  As mentioned above it helps make friendly nitric oxide (eNOS Endothelial Nitric Oxide Synthase. Type of enzyme involved with various physiological signals and maintenance activities with nitric oxide. ).  On the other hand, it actually helps regulate the main gene signal involved with inflammation5 (NF-kappaB Protein complex that controls DNA transcription and is involved with cellular responses to stress, cytokines, free radicals, UV radiation, oxidized LDL, and infections. ), in turn reducing inflammation and preventing the release of the inflammatory form of nitric oxide (iNOS Inducible Nitric Oxide Synthase. This enzyme influences genes located in the neuro-immune and cardiovascular system and provides immune defense against pathogens and contributes to disease progression including neurogenic inflammation (iNOS2). ).

One type of cardiovascular toxin common to Americans is that produced from poor dental hygiene.  In fact, unfriendly bacteria in your mouth can easily enter your circulation and release toxicity that causes platelets to stick together, significantly increasing your risk for a heart attack or stroke.  GSE has been shown to reduce the oxidative stress associated with such bacterial toxins, directly turning off the unfriendly nitric oxide production (iNOS Inducible Nitric Oxide Synthase. This enzyme influences genes located in the neuro-immune and cardiovascular system and provides immune defense against pathogens and contributes to disease progression including neurogenic inflammation (iNOS2). ) they cause.  The researchers concluded6, “Our findings demonstrate that proanthocyanidins have potent antioxidant properties and should be considered a potential agent in the prevention of periodontal diseases.”  Other research also shows GSE helps keep platelets7 from sticking together, along with the fact it helps strengthen gum tissue (GSE helps any collagen structure); it can be seen to assist this issue in multiple ways.

Smokers are famous for having sticky platelets because cigarettes have at least 80 chemical toxins that irritate platelets, which promote inappropriate clotting, increasing the risk for a heart attack or stroke.  A study showed that GSE significantly reduced the platelet stickiness8 in male smokers.

A known method of inducing experimental heart injury is to expose rats to the cardiotoxin isoproterenol.  Researchers found that GSE protected the heart9 from experimentally induced isoproterenol injury. The researchers concluded that grape seed proanthocyanidins have “a significant effect in the protection of the heart.”

Another common cardiovascular irritant faced by millions of Americans is the toxins produced from an overgrowth of candida albicans in the digestive tract and/or sinuses.  While candida can enter the circulation and infect your heart, this only happens in seriously immune compromised patients.  For most people it is the toxins of candida that act as a cardiovascular irritant by entering your circulation, which also makes you feel tired, irritable, and foggy.  A groundbreaking study shows that GSE directly reduced candida overgrowth10 as well as extended the survival of mice subjected to experimental candida overgrowth.

In one study rats were exposed to lead, with one group getting lead and GSE.  While the GSE did not detoxify the lead, it did protect the rats from cardiovascular damage11.  Lead exposed rats with no GSE protection developed significantly high blood pressure and elevated heart rate, whereas GSE protected rats did not develop these cardiovascular problems when exposed to lead.

Chinese researchers proved that GSE directly boosted antioxidant activity in heart cells12, in turn protecting heart cells from free radical induced death.  In their next experiment they tested the chemotherapy drug Adriamycin, which has a limited dose in clinical practice because it is highly toxic to the heart.  They showed that pretreating animals with GSE significantly reduced the heart-related toxicity13, including cell death and DNA fragmentation.  They identified that this was partly due to antioxidant mechanisms but also found GSE was helping regulate genes that helped the heart cells withstand the stress of the toxin.  In addition to helpful protection during chemotherapy, findings of this type suggest that GSE would help those who have to be on toxic drugs regularly – such as those on organ transplant medication or long-term antibiotics.

GSE exerts extraordinary protection to the heart in the face of diabetes.  In diabetes excessive blood sugar links the flexible heart muscle like cement through a process known as glycation (AGEs – advanced glycation end products).  This results in eventual heart failure and heart attacks.  A recent detailed molecular animal study showed that GSE reduced the formation of AGEs in the heart14, maintained the health of mitochondria Organelle found in cells that produce ATP or chemical energy. Also involved with cell signaling, cellular differentiation, cell death, cell growth, along with heme and steroid synthesis. (cell engines), and preserved the healthy structure of the heart.  GSE was shown to work at the gene transcription level, down-regulating the primary inflammatory gene signal NF-kappaB Protein complex that controls DNA transcription and is involved with cellular responses to stress, cytokines, free radicals, UV radiation, oxidized LDL, and infections. .  The researchers concluded that GSE “plays an important role against diabetic cardiomyopathy. With the decreasing of AGEs, it can ameliorate glycation associated cardiac damage.  This study may provide a new recognition of natural medicine for the treatment of diabetic cardiomyopathy.”

Other researchers found that GSE directly turns down the gene signaling system that causes AGEs to form, while simultaneously reducing oxidative damage.  This would not only be helpful to the heart but also helpful to your entire circulatory system15 if your blood sugar is running high.  The researchers concluded that GSE “may have therapeutic potential in the prevention and treatment of vascular complications in diabetic patients.”

It can be understood that the fundamental role of GSE in your body is one of added protection against multiple stressors in life.  In addition to all the cardiovascular benefits recent research has also shown that GSE reduces the formation of amyloid plaque in the brain that causes Alzheimer’s disease16 by 30 to 35 percent while maintaining cognitive function at a higher level.  GSE also protects your skin from UV radiation17, by helping as an antioxidant and also helping at the gene transcription level by modulating NF-kappaB Protein complex that controls DNA transcription and is involved with cellular responses to stress, cytokines, free radicals, UV radiation, oxidized LDL, and infections. .

In animal studies GSE has been shown to help break down stored fat from fat cells (lipolysis) as well as reduce food intake.  The effect of GSE on food intake in humans was tested over a three day period in a variety of people of different body composition and age.  Those who were overweight18 had a four percent reduction in food intake.  This preliminary study suggests that GSE will help an overweight person’s willpower to eat less food should they decide to cut back on calorie intake.

The really exciting news is what GSE is doing at the gene level in relationship to fat, inflammation, diabetes, cholesterol, and triglycerides.

It is well known in human physiology19 that fat produces hormone messengers such as leptin and adiponectin Protein hormone that modulates metabolism including glucose and fatty acid catabolism. High levels are associated with low body fat. as well as inflammatory signals such as TNFa Cytokine involved with systemic inflammation and regulation of immune cells. It is able to induce cell death, and inhibits tumorigenesis and viral replication. When dysfunctional it is associated with a number of disease processes. and IL6.  It is also known that once inflammation starts in fat, it turns on your liver’s production of CRP C-reactive protein. It is an acute phase protein that increases during systemic inflammation. It is a general way to assess cardiovascular disease risk. A more sensitive test for heart disease risk is hs-CRP, highly sensitive CRP. , another inflammatory messenger.  Excess and low-grade CRP C-reactive protein. It is an acute phase protein that increases during systemic inflammation. It is a general way to assess cardiovascular disease risk. A more sensitive test for heart disease risk is hs-CRP, highly sensitive CRP. , TNFa Cytokine involved with systemic inflammation and regulation of immune cells. It is able to induce cell death, and inhibits tumorigenesis and viral replication. When dysfunctional it is associated with a number of disease processes., and IL6 are all associated with increased risk for cardiovascular disease.  This inflammatory situation is accompanied by high levels of leptin in your blood (leptin resistance), high triglycerides, high cholesterol, and low adiponectin Protein hormone that modulates metabolism including glucose and fatty acid catabolism. High levels are associated with low body fat. .  As adiponectin Protein hormone that modulates metabolism including glucose and fatty acid catabolism. High levels are associated with low body fat. drops low then insulin resistance is caused in the liver, eventually resulting in type 2 diabetes.  Correcting leptin problems by following the Leptin Diet, exercising, and using dietary supplements that foster improved leptin function go a long way toward fixing this problem.  Of course, any nutrient that boosts adiponectin Protein hormone that modulates metabolism including glucose and fatty acid catabolism. High levels are associated with low body fat. and lowers these inflammatory messengers will not only improve metabolism to assist weight management but also reduce the risk for heart disease.

A recent animal study induced this exact metabolic problem profile by feeding rats a high fat diet.  The researchers found that GSE reversed the metabolic problems20, lowering the inflammatory signals CRP C-reactive protein. It is an acute phase protein that increases during systemic inflammation. It is a general way to assess cardiovascular disease risk. A more sensitive test for heart disease risk is hs-CRP, highly sensitive CRP. , IL6, and TNFa Cytokine involved with systemic inflammation and regulation of immune cells. It is able to induce cell death, and inhibits tumorigenesis and viral replication. When dysfunctional it is associated with a number of disease processes..  Of great importance, the GSE boosted the production of adiponectin Protein hormone that modulates metabolism including glucose and fatty acid catabolism. High levels are associated with low body fat. , indicating that GSE can help prevent metabolic deterioration to the point of type 2 diabetes. 

Novel animal research is showing that GSE helps your liver clear cholesterol21 and turns on fat burning gene signals that help lower triglycerides22.  While excess food consumption will overload these mechanisms, those who follow the Leptin Diet and exercise are likely to get a nice metabolic enhancement by consuming GSE as part of their weight management program.

One of the main problems that causes LDL cholesterol Low-density lipoprotein. It is a group of lipids and proteins that allow lipids like cholesterol, triglycerides, and fat soluble nutrients (Vitamin A, D, E , K, Q 10, carotenes) to be transported with the water-based bloodstream. to wind up in plaque is that it is damaged (oxidized by free radicals or toxins), at which point it is taken up by macrophages and brought into the lining of arteries.  One key to cardiovascular health is preventing the damage to LDL.  GSE is a water-soluble nutrient and is not found in LDL, thus it is not directly protecting the membrane of LDL as do fat soluble antioxidants like tocotrienols, carotenes, Q10, and R-alpha lipoic acid.  Rather, GSE acts as an antioxidant police force in the circulatory fluid (blood plasma) and interstitial fluid of the arterial wall.  Research shows that GSE directly reduces the oxidation of LDL cholesterol Low-density lipoprotein. It is a group of lipids and proteins that allow lipids like cholesterol, triglycerides, and fat soluble nutrients (Vitamin A, D, E , K, Q 10, carotenes) to be transported with the water-based bloodstream. by helping prevent free radicals from punching the LDL in the nose.

In 2000 a study of 40 people with high cholesterol found that a combination of 100 mg GSE twice a day and 200 mcg chromium twice a day lowered LDL cholesterol Low-density lipoprotein. It is a group of lipids and proteins that allow lipids like cholesterol, triglycerides, and fat soluble nutrients (Vitamin A, D, E , K, Q 10, carotenes) to be transported with the water-based bloodstream. 23 by 20 percent.  The GSE also cut autoantibodies to oxidized LDL cholesterol Low-density lipoprotein. It is a group of lipids and proteins that allow lipids like cholesterol, triglycerides, and fat soluble nutrients (Vitamin A, D, E , K, Q 10, carotenes) to be transported with the water-based bloodstream. in half, compared to the control group (indicating cholesterol was less likely to be forming plaque in the GSE supplemented group).  Interestingly, these doses of both nutrients are on the conservative side.

Grape seed extract is a powerful protector of your heart and general circulation.  It favorably changes a number of metabolic signals toward reduced risk for cardiovascular disease.  It is proven to act as a water-soluble antioxidant and helps lower key inflammatory signals such as CRP C-reactive protein. It is an acute phase protein that increases during systemic inflammation. It is a general way to assess cardiovascular disease risk. A more sensitive test for heart disease risk is hs-CRP, highly sensitive CRP. , IL6, and TNFa Cytokine involved with systemic inflammation and regulation of immune cells. It is able to induce cell death, and inhibits tumorigenesis and viral replication. When dysfunctional it is associated with a number of disease processes..  It is also proven to act at the gene transcription level, helping clear cholesterol, reduce triglycerides, and directly helping the key inflammatory gene signal known as NF-kappaB Protein complex that controls DNA transcription and is involved with cellular responses to stress, cytokines, free radicals, UV radiation, oxidized LDL, and infections. . As far as GSE is concerned, the higher the dose the greater the protection. 

GSE is one of the marvels of Mother Nature.

Read More:  Antioxidants News, Blood Pressure News, Cardiovascular Health News, Cholesterol News, Circulation News, Inflammation News, Weight Management News
Tags: Cardio Helper, grape seed extract, GSE, LDL cholesterol, OPC, platelets,
Referenced Studies: ^ Red Wine Proanthocyanidins and Longevity  Nature  R. Corder, W. Mullen, N. Q. Khan, S. C. Marks, E. G. Wood, M. J. Carrier1 & A. Crozier. ^ Red Wine Reduces Fat Intake From a Meal  International Journal of Obesity  S Pal, M Naissides and J Mamo. ^ Grape Seed Extracts Relax Blood Vessels  Ann N Y Acad Sci.  Fitzpatrick DF, Bing B, Maggi DA, Fleming RC, O’Malley RM. ^ Grape Seed Extract Helps Relax Your Circulation  Clin Sci (Lond).  Edirisinghe I, Burton-Freeman B, Tissa Kappagoda C. ^ Grape Seed Extract has Potent Anti-Inflammatory Properties  J Agric Food Chem.  Terra X, Valls J, Vitrac X, Mérrillon JM, Arola L, Ardèvol A, Bladé C, Fernandez-Larrea J, Pujadas G, Salvadó J, Blay M. ^ Grape Seed Extract Promotes Dental Health While Protecting Circulation  J Periodontol.  Houde V, Grenier D, Chandad F. ^ Grape Seed Extracts Reduce Platelet Stickiness   J Cardiovasc Pharmacol.  Vitseva O, Varghese S, Chakrabarti S, Folts JD, Freedman JE. ^ Grape Seed Extract Helps Platelets of Male Smokers  J Med Food.  Polagruto JA, Gross HB, Kamangar F, Kosuna K, Sun B, Fujii H, Keen CL, Hackman RM. ^ Grape Seed Extract Protects Heart from Toxicity  Life Sci.  Karthikeyan K, Sarala Bai BR, Niranjali Devaraj S. ^ Grape Seed Extract Inhibits Growth of Candida Albicans  Phytomedicine.  Han Y. ^ Grape Seed Extract Protects Against Lead Exposure  Pak J Biol Sci  Badavi M, Mehrgerdi FZ, Sarkaki A, Naseri MK, Dianat M. ^ Grape Seed Extract Protects Heart Cells  J Agric Food Chem.  Du Y, Guo H, Lou H. ^ Grape Seed Extract Protects Heart from Extreme Toxicity  Eur J Pharmacol.  Du Y, Lou H. ^ Grape Seed Extract Protects the Heart in Diabetes  J Cardiovasc Pharmacol.  Cheng M, Gao HQ, Xu L, Li BY, Zhang H, Li XH. ^ Grape Seed Extracts Inhibit Glycation Damage in Circulatory System  J Cardiovasc Pharmacol.  Zhang FL, Gao HQ, Shen L. ^ Grape Seed Extract Reduces Alzheimer’s Plaque  The Journal of Neuroscience  Jun Wang, Lap Ho, Wei Zhao, Kenjiro Ono, Clark Rosensweig, Linghong Chen, Nelson Humala, David B. Teplow, and Giulio M. Pasinetti. ^ Grape Seed Extracts Protect Against UV Sun Damage  Free Radic Biol Med.  Mantena SK, Katiyar SK. ^ Grape Seed Extract Reduces Food Intake in Overweight Humans  Eur J Clin Nutr.  Vogels N, Nijs IM, Westerterp-Plantenga MS. ^ How Obesity Leads to Type II Diabetes is Now Very Clear  Int J Obes (Lond).   Zamboni M, Di Francesco V, Garbin U, Fratta Pasini A, Mazzali G, Stranieri C, Zoico E, Fantin F, Bosello O, Cominacini L. ^ Grape Seed Extract Lowers Inflammation and Boosts Adiponectin  Nutr Biochem.  Terra X, Montagut G, Bustos M, Llopiz N, Ardèvol A, Bladé C, Fernández-Larrea J, Pujadas G, Salvadó J, Arola L, Blay M. ^ Grape Seed Extracts Help Your Liver Clear Cholesterol  FASEB J.   Del Bas JM, Fernández-Larrea J, Blay M, Ardèvol A, Salvadó MJ, Arola L, Bladé C. ^ Grape Seed Extracts Help Turn On Gene Signals that Lower Triglycerides  Mol Nutr Food Res.  Del Bas JM, Ricketts ML, Baiges I, Quesada H, Ardevol A, Salvadó MJ, Pujadas G, Blay M, Arola L, Bladé C, Moore DD, Fernandez-Larrea J. ^ GSE and Chromium Help Lower Cholesterol in Humans  J Med.  Preuss HG, Wallerstedt D, Talpur N, Tutuncuoglu SO, Echard B, Myers A, Bui M, Bagchi D.

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Hawthorn for Your Heart

Tuesday, May 07, 2013
By: Byron J. Richards,
Board Certified Clinical Nutritionist

Widely recognized as a cardiovascular tonic, hawthorn berry relaxes the heart while supporting its ability to produce and sustain energetic output. Since the heart never gets a vacation, the rejuvenating effect of hawthorn may be the next best thing. Hawthorn berries are used in traditional medicine1 in the treatment of chronic heart failure, high blood pressure, irregular heart beat, and digestive problems. They also have mild diuretic properties and a beneficial impact on cholesterol. 

Hawthorn berries contain a wide range of flavonoids Plant compound that is associated with pigmentation. Flavonoids have been shown to modify allergens, viruses, inflammation, and various carcinogens. Found in green tea, citrus, berries, onions, parsley, red wine, dark chocolate, and others., which are responsible for their diverse mechanisms of operation. These flavonoids Plant compound that is associated with pigmentation. Flavonoids have been shown to modify allergens, viruses, inflammation, and various carcinogens. Found in green tea, citrus, berries, onions, parsley, red wine, dark chocolate, and others. include hyperoside, rutin, quercetin, vitexin, epicatechin, catechin, and proanthocyanidins. Hawthorn also contains germ-controlling phenols such as chlorogenic acid. 

There are several varieties of hawthorn. The preferred form for nutritional supplementation is Crataegus oxyacantha, which is standardized at 1.8% to contain the heart-friendly flavonoid vitexin. Common doses used in hawthorn studies range from 160-1800 mg, with the most common doses tested in the range of 600-900 mg per day. 

Hawthorn is widely used in Europe as an approved treatment for the initial stages of heart failure (Class I and II), with the goal of improving patients without the use of drugs. It has also been used to help patients with Class III heart failure, in conjunction with medical treatment.

Heart failure implies that the heart is not fit enough to supply blood for the body’s needs. Common symptoms include shortness of breath, coughing, fluid retention (especially ankle swelling), fatigue, and a reduced ability to exercise. The severity of the problem is classified by the heart’s performance based on a four-class scale known as the New York Heart Association Functional Classification.
• Class I: no limitation is experienced in any activities; there are no symptoms from ordinary activities. 
• Class II: slight, mild limitation of activity; the patient is comfortable at rest or with mild exertion. 
• Class III: marked limitation of any activity; the patient is comfortable only at rest.
• Class IV: any physical activity brings on discomfort and symptoms occur at rest.

A recent scientific review of all double-blind controlled studies on hawthorn2 (of which there are many) found a “significant benefit in symptom control and physiologic outcomes from hawthorn extract as an adjunctive treatment for chronic heart failure.” Hawthorn was shown to improve the heart’s maximum workload, which resulted in improved exercise tolerance. Shortness of breath and fatigue were significantly improved, and the heart’s ability to use oxygen was enhanced. These are very significant findings for a dietary supplement.

Hawthorn has a relaxing effect3 on the arteries, improving circulation and facilitating healthy blood pressure. Hawthorn has been shown to enhance the flow of blood4 through the heart, while helping the heart beat tone up (inotropic effect). In fact, hawthorn was found to be far friendlier and more energy efficient than drugs in helping the heart muscle contract5 to produce an effective beat. A randomized controlled trial showed that hawthorn lowered diastolic blood pressure6 (the lower number) in patients with type II diabetes.

A flavonoid contained in hawthorn has been shown to have a natural regulating effect on angiotensin converting enzyme7, acting as a natural ACE inhibitor. ACE converts the inactive form of angiotensin (angiotensin I) into the active vasoconstrictor (angiotensin II). A system with inadequate brakes leads to higher blood pressure. Better tone in this system also supports kidney health.

During times of circulatory stress, immune cells may release an enzyme called human neutrophil elastase8 (HNE). While this is a normal enzyme, excess amounts can induce wear and tear. Hawthorn berry helps to modulate the release of HNE, thereby supporting cardiovascular health.

Hawthorn has also been shown to protect animals from experimentally induced heart attack9 by maintaining antioxidant status and boosting oxygen utilization within the heart. In another experiment, researchers showed that hawthorn protected the liver10 from adverse changes during a heart attack, indicating hawthorn’s protective effect beyond just the heart and circulation.

In a study of rabbits fed a high cholesterol diet, those on hawthorn had a 23% reduction in total cholesterol11 and a 22% reduction in triglycerides. Researchers believed hawthorn helped reduce cholesterol absorption from the diet. This finding is similar to another animal study, which not only found similar reductions in cholesterol12 and triglycerides, but also found that damage to the liver did not occur at the same rate with hawthorn supplementation. Yet another animal study found that hawthorn helped activate LDL receptors13 in the liver, promoting the natural clearance of cholesterol through the bile.

Hawthorn helps prevent free radical-induced oxidation14 of LDL cholesterol Low-density lipoprotein. It is a group of lipids and proteins that allow lipids like cholesterol, triglycerides, and fat soluble nutrients (Vitamin A, D, E , K, Q 10, carotenes) to be transported with the water-based bloodstream. , a step that must occur before LDL can form plaque in arteries. It was also shown to protect vitamin E from damage and synergistically boost vitamin E status by 18%-20%.

While hawthorn has been extensively studied and widely used in Europe for heart failure, its general effect on the heart is relaxing and toning, improving overall fitness. Furthermore, hawthorn’s multiple actions in the circulatory system are synergistic with many other cardio-friendly nutrients toward the goal of improved cardiovascular health.

Referenced Studies: ^ Hawthorn Uses, Inflammation,  Anti-Oxidant, Mild Germ Killer  J Agric Food Chem.  Tadic VM, Dobric S, Markovic GM, Dordevic SM, Arsic IA, Menkovic NR, Stevic T. ^ Hawthorn Helps Heart Failure  Cochrane Database of Systematic Reviews  Pittler MH, Guo R, Ernst E. ^ Hawthorn Relaxes Arteries   Life Sci.   Chen ZY, Zhang ZS, Kwan KY, Zhu M, Ho WK, Huang Y. ^ Hawthorn Helps Blood Flow in Heart and Heart Strength  Arzneimittelforschung.   Schüssler M, Hölzl J, Fricke U. ^ Hawthorn is a Friendly Way to Strengthen Heart Beats  Arzneimittelforschung.   Pöpping S, Rose H, Ionescu I, Fischer Y, Kammermeier H. ^ Hawthorn Lowers Diastolic Blood Pressure in Diabetics  Br J Gen Pract.  Walker AF, Marakis G, Simpson E, Hope JL, Robinson PA, Hassanein M, Simpson HC. ^ Flavonoid in Hawthorn Acts as Natural ACE Inhibitor  The Japanese Journal of Pharmacology.  Shinji UCHIDA, Nobuhiko IKARI, Hisashi OHTA2, Masami NIWA, Gen-ichiro NONAKA, Itsuo NISHIOKA and Masayori OZAKI.  ^ Hawthorn Protects Circulation from Stress  Arzneimittelforschung.   Chatterjee SS, Koch E, Jaggy H, Krzeminski T. ^ Hawthorn Protects Against Experimentally Induced Heart Attack  J Pharm Pharmacol.  Jayalakshmi R, Niranjali Devaraj S. ^ Hawthorn is Also a Liver Protector  J Med Food.  Thirupurasundari CJ, Jayalakshmi R, Niranjali Devaraj S. ^ Hawthorn Reduces Cholesterol and Triglycerides  J Nutr.  Zhang Z, Ho WK, Huang Y, James AE, Lam LW, Chen ZY. ^ Hawthorn Helps Lower Cholesterol, Protect Liver from High Fat Diet  Indian J Biochem Biophys.  Shanthi S, Parasakthy K, Deepalakshmi PD, Devaraj SN. ^ Hawthorn Helps the Liver Clear LDL Cholesterol  Atherosclerosis.   Rajendran S, Deepalakshmi PD, Parasakthy K, Devaraj H, Devaraj SN. ^ Hawthorn Helps Protect LDL Cholesterol from Damage   J Nutr Biochem.  Zhang Z, Chang Q, Zhu M, Huang Y, Ho WK, Chen Z.

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How to Prevent Vaccine Injury

Friday, March 08, 2013
By: Byron J. Richards,
Board Certified Clinical Nutritionist

It is a colossal failure on the part of our government not to warn parents of the actual risks associated with vaccines.  The blind insistence that vaccines are safe and effective is not supported by science, at least for a significant number of our children.  There are now 25,000 children per year who develop autism (one in 150), a problem that has expanded in direct proportion to the increase in vaccinations.  How do you know if your child is at risk?

The government’s primary goal appears to be to prevent parents, en masse, from refusing to vaccinate their children.  To prevent such a “run on the public health bank” all caution is being recklessly thrown to the wind.  American children are now the most vaccinated people in the world.  What are we actually doing?  The vaccination problem needs to be objectively solved so that public health is maintained, yet needless vaccine injury is avoided.

It should not be of any great comfort to parents that scientists hardly understand how the immune system works.  The simplistic idea that vaccines offer protection against disease has an element of truth along with a significant element of risk.  This article explores the risk in greater depth.  I first explain what is known about the nature of the risk, and follow with some natural options that can help. 

Giving a fully active virus as a vaccine would obviously cause the disease.  On the other hand, a weakened or deadened form of the virus may not produce much of an immune response, thereby making the vaccine worthless.  This problem has been “solved” by combining the weakened disease with an immune activator called an adjuvant.

An adjuvant does not contain the disease, rather it is intended to initiate the first step in fighting an infection – the inflammatory response.  This is like giving a general wake-up call to the immune system.  This can be done with an irritant or a more specific toxin the immune system is likely to recognize based on eons of exposure.

In the irritant category, the most common adjuvants used in vaccines your child will get are salts of aluminum (aluminum phosphate and aluminum hydroxide).  The safety of aluminum salts has been called into question following the poor health of many Gulf War Veterans who received multiple aluminum adjuvant vaccinations.  Many scientists consider that their poor health was caused by the adjuvants in the vaccines they were given.  In 2003 French researchers identified aluminum hydroxide vaccine adjuvants1 as the cause of a new disease consisting of pain and chronic fatigue, noting similarities to problems Gulf War soldiers experienced.

In a recent study mice were given aluminum hydroxide at doses comparable to those of the Gulf War soldiers.  The mice were extensively tested for cognitive ability, and their nervous systems analyzed upon sacrifice.  The results showed that aluminum hydroxide caused nerve-related motor defects2.  Analysis of brain tissue showed 255 percent increase in inflammatory markers along with 35 percent loss of motor neurons. 

It has been more than a year since this study was published.  Why isn’t the CDC doing the same experiment with the adjuvant load from their recommended vaccine schedule?  Any substance that is adversely neurotoxic in an adult is likely to be more neurotoxic in the evolving nervous system of a baby.  Not following up on this is gross negligence on the part of the CDC.

Another common adjuvant is bacterial endotoxin (the outer membrane of the cell wall of Gram-negative bacteria), also known as lipopolysaccharide or LPS.  Since we have been battling bacteria since the beginning of our evolution, our immune systems recognize LPS as an invasion – setting off a powerful inflammatory immune system reaction.  The toxicity of any bacterial infection relates to LPS.

Scientists at the National Institutes of Health3 freely acknowledge that the pro-inflammatory effects of adjuvants in vaccines “underlie many of the observed toxic effects.”  The new science shows very clearly that all the inflammation generated by adjuvants is actually not necessary for activating the immune response.

This means that our government is sticking by a vaccine program that relies on firing a toxic shotgun at the immune system even though they know a laser-guided approach would have much less risk of vaccine injury from direct toxicity.  The problem for our government is that they don’t currently have the ability to make safer vaccines, thus they blindly defend the safety of a very crude approach and refuse to conduct tests that would easily show that the current vaccine program is not safe.  It is quite clear that an inflamed nervous system4 is an undeniable feature in autism.

Nuclear Factor kappa-B is the “brain” residing within every cell of your body, including cells of your nervous system.  It is a gene transcription factor, meaning that it tells your cells how to behave depending on what is happening.  When everything runs smoothly, NF-kappaB Protein complex that controls DNA transcription and is involved with cellular responses to stress, cytokines, free radicals, UV radiation, oxidized LDL, and infections. has its feet up on the lawn chair in a relaxed mode of operation.  Under stress NF-kappaB Protein complex that controls DNA transcription and is involved with cellular responses to stress, cytokines, free radicals, UV radiation, oxidized LDL, and infections. initiates survival strategies.  NF-kappaB Protein complex that controls DNA transcription and is involved with cellular responses to stress, cytokines, free radicals, UV radiation, oxidized LDL, and infections. is the main regulator of all inflammatory and immune responses, and is intimately involved with the healthy function of your nervous system.  NF-kappaB Protein complex that controls DNA transcription and is involved with cellular responses to stress, cytokines, free radicals, UV radiation, oxidized LDL, and infections. is an active intelligence within your cells.  The last thing you would ever want to do is mess up NF-kappaB Protein complex that controls DNA transcription and is involved with cellular responses to stress, cytokines, free radicals, UV radiation, oxidized LDL, and infections. .

Adjuvants, due to their intentionally inflammatory mode of operation, activate NF-kappaB Protein complex that controls DNA transcription and is involved with cellular responses to stress, cytokines, free radicals, UV radiation, oxidized LDL, and infections. .  This is done to ramp-up the immune system so it can “see” the weakened virus in the vaccine.  The million dollar question is:  “How much NF-kappaB Protein complex that controls DNA transcription and is involved with cellular responses to stress, cytokines, free radicals, UV radiation, oxidized LDL, and infections. activation can children take before their NF-kappaB Protein complex that controls DNA transcription and is involved with cellular responses to stress, cytokines, free radicals, UV radiation, oxidized LDL, and infections. systems overheat and set a fire in their brain called autism?”  When NF-kappaB Protein complex that controls DNA transcription and is involved with cellular responses to stress, cytokines, free radicals, UV radiation, oxidized LDL, and infections. overheats it generates large amounts of inflammatory immune system messengers (like TNFa Cytokine involved with systemic inflammation and regulation of immune cells. It is able to induce cell death, and inhibits tumorigenesis and viral replication. When dysfunctional it is associated with a number of disease processes. and IL6) and massive numbers of free radicals that damage nerve cells.

If a child is already acutely inflamed then the NF-kappaB Protein complex that controls DNA transcription and is involved with cellular responses to stress, cytokines, free radicals, UV radiation, oxidized LDL, and infections. pump has already been primed and the risk for vaccine injury is greater.  Acute inflammation is caused by illness, injury, surgery, poor diet, and stress at home.  This problem is magnified if the child had a history of inflammation while in the womb, was born prematurely, or had health struggles during the first few years of life.  Even a previous round of vaccines can prime the inflammatory NF-kappaB Protein complex that controls DNA transcription and is involved with cellular responses to stress, cytokines, free radicals, UV radiation, oxidized LDL, and infections. pump.  Environmental toxicity is another factor that cannot be ignored, as is the health of the mother prior to and during pregnancy.  A mother’s obesity and eating habits have a significant effect on the nerve health of her child.

The main point to understand is that if the NF-kappaB Protein complex that controls DNA transcription and is involved with cellular responses to stress, cytokines, free radicals, UV radiation, oxidized LDL, and infections. system is already on the edge of overheating due to other factors, then the intentional pushing of this system with vaccines poses a serious risk to the child.  Multiple vaccines given at one time, with multiple pro-inflammatory adjuvants, obviously increase the risk.  Any person who objectively reviews the science on this issue could reach no other conclusion.

The issue of NF-kappaB Protein complex that controls DNA transcription and is involved with cellular responses to stress, cytokines, free radicals, UV radiation, oxidized LDL, and infections. is so important that the next generation of vaccines5 will utilize it in an attempt to make less toxic vaccines6 (the laser-guided approach rather than the shotgun).  While NF-kappaB Protein complex that controls DNA transcription and is involved with cellular responses to stress, cytokines, free radicals, UV radiation, oxidized LDL, and infections. -targeted vaccines will be less blatantly toxic, making them free of adverse side effects is another story altogether.  Manipulating NF-kappaB Protein complex that controls DNA transcription and is involved with cellular responses to stress, cytokines, free radicals, UV radiation, oxidized LDL, and infections. is playing with the essence of the life force of a cell.  At any given time numerous on’s and off’s relate to how NF-kappaB Protein complex that controls DNA transcription and is involved with cellular responses to stress, cytokines, free radicals, UV radiation, oxidized LDL, and infections. naturally works to maintain health.  The new vaccines will turn on the inflammatory aspect of NF-kappaB Protein complex that controls DNA transcription and is involved with cellular responses to stress, cytokines, free radicals, UV radiation, oxidized LDL, and infections. , which could easily upset the applecart in some other needed aspect of health. 

No matter how good research scientists are at developing new vaccines, there will always be a percentage of at-risk-already-inflamed children who are likely to respond in a poor manner.  Vaccine safety is not just about better vaccines; it’s also about protecting those who are most likely to have poor reactions to them.  It is not possible to have a good public health policy for disease prevention that fails to take this fact into account.

Mother Nature provides an array of NF-kappaB Protein complex that controls DNA transcription and is involved with cellular responses to stress, cytokines, free radicals, UV radiation, oxidized LDL, and infections. modulating compounds.  Unlike drugs, nutrients are far more compatible with genes, since we evolved using nutrition to assist survival.  When we provide our cells with needed nutrients, NF-kappaB Protein complex that controls DNA transcription and is involved with cellular responses to stress, cytokines, free radicals, UV radiation, oxidized LDL, and infections. seems to know what to do with them.  It is very clear that NF-kappaB Protein complex that controls DNA transcription and is involved with cellular responses to stress, cytokines, free radicals, UV radiation, oxidized LDL, and infections. uses nutrition to help cool itself off – like a tall glass of ice water on a hot day.

A diet rich in fresh fruits and vegetables is the foundation for NF-kappaB Protein complex that controls DNA transcription and is involved with cellular responses to stress, cytokines, free radicals, UV radiation, oxidized LDL, and infections. anti-inflammatory nutrition.  When a mother eats this type of diet during pregnancy and while nursing she passes tremendous benefit to her child.  It is now clear that such good health habits are passed along, a type of fetal programming of the taste system, wherein the child is now more likely to eat healthfully and consequently have better function of NF-kappaB Protein complex that controls DNA transcription and is involved with cellular responses to stress, cytokines, free radicals, UV radiation, oxidized LDL, and infections. .

On top of a good diet, certain “super nutrients” significantly help NF-kappaB Protein complex that controls DNA transcription and is involved with cellular responses to stress, cytokines, free radicals, UV radiation, oxidized LDL, and infections. behave in a healthy manner.  These help NF-kappaB Protein complex that controls DNA transcription and is involved with cellular responses to stress, cytokines, free radicals, UV radiation, oxidized LDL, and infections. not get overheated or too bent out of shape.  The following list of nutrients is by no means complete.  I’ve selected them because I’ve used them for years and I know they work.  Plenty of science supports their common sense use, for young and old alike.

Such extra nutrient support can be used as needed to:
1) Calm down nerves from existing life stress or a pattern of wear and tear
2) Calm down nerves following an inflammatory event, such as vaccinations
3) Stabilize nerves that are struggling
4) Generally improve cognitive function and nerve development

The five nutrients I’ve selected for discussion are the tocotrienol Specialized form of vitamin E. Powerful antioxidant showing positive benefits for cholesterol, cardiovascular, neurological health and cancer risk reduction. form of vitamin E, grape seed extract, lipoic acid, acetyl-l-carnitine, and the herb silymarin.  They offer a treasure trove of NF-kappaB Protein complex that controls DNA transcription and is involved with cellular responses to stress, cytokines, free radicals, UV radiation, oxidized LDL, and infections. modulating nerve and energy support nutrients.

Tocotrienols are a special form of vitamin E with unique antioxidant properties that are in many ways superior to plain vitamin E.  For example, a recent study showed that tocotrienols offered superior protection to the nervous system from methylmercury7 – a potent nerve toxin.  It is very clear that tocotrienols work by modulating NF-kappaB Protein complex that controls DNA transcription and is involved with cellular responses to stress, cytokines, free radicals, UV radiation, oxidized LDL, and infections. 118, are a superior brain protecting nutrient9, and are also helpful for inflammation in the circulatory system10 by reducing NF-kappaB Protein complex that controls DNA transcription and is involved with cellular responses to stress, cytokines, free radicals, UV radiation, oxidized LDL, and infections. .
Silymarin or Milk Thistle is an herb that is commonly used to protect the liver as well as to help it clear toxins.  Silymarin also works by modulating NF-kappaB Protein complex that controls DNA transcription and is involved with cellular responses to stress, cytokines, free radicals, UV radiation, oxidized LDL, and infections. 118 to turn down inflammation.  One study showed it was able to stop the LPS induced toxicity12 in brain cells.  Another study showed it stopped the autoimmune driven damage13 to nerves (demyelination) while reducing inflammation. 

Grape seed extracts contain proanthocyanidins that have also been shown to directly turn off LPS toxicity1914 by turning down NF-kappaB Protein complex that controls DNA transcription and is involved with cellular responses to stress, cytokines, free radicals, UV radiation, oxidized LDL, and infections. .  Taking the extract before damage to the nerves, as from alcohol consumption, helps prevent brain damage15.  Taking the extract after damage to nerves is already in progress helps stop the damage16.  Grape seed extracts are another top choice for nerve protection.

R-Alpha Lipoic Acid and Acetyl-L-Carnitine work synergistically to restore mitochondrial energy production17 in nerve cells.  It is now believed that one factor involved with vaccine injury is poor mitochondrial function.  Lipoic Acid is another nutrient now proven to lower NF-kappaB Protein complex that controls DNA transcription and is involved with cellular responses to stress, cytokines, free radicals, UV radiation, oxidized LDL, and infections. 18 and reduce the inflammation associated with LPS toxicity1914.  Acetyl-l-Carnitine has been extensively studied for its role in memory and cognitive function.  It also exerts powerful nerve protection20 by a variety of different mechanisms.

As you can see, plenty of science supports the use of nutrition to help out the brain, and this is just a sample of some of the better options.  These nutrients are typically quite easy to mix into juice, apple sauce, or yogurt.  The tocotrienol Specialized form of vitamin E. Powerful antioxidant showing positive benefits for cholesterol, cardiovascular, neurological health and cancer risk reduction. oil can be squeezed from the softgel capsule directly into the mouth.  Powders can be mixed in water and administered with a dropper during nursing.  Nursing moms can take any of these nutrients, which will transfer in her milk.

Nutrition excels at the safe and natural regulation of inflammation, including nerve inflammation, primarily by helping NF-kappaB Protein complex that controls DNA transcription and is involved with cellular responses to stress, cytokines, free radicals, UV radiation, oxidized LDL, and infections. work normally.

Related article:  CNN Helps Autism Debacle Blow Up in Government’s Face

Referenced Studies: ^ Aluminum Vaccine Adjuvant Linked to Chronic Fatigue and Pain  Rev Neurol (Paris).  Gherardi RK. ^ Aluminum Vaccine Adjuvant is Nerve Toxic  Neuromolecular Med.  Petrik MS, Wong MC, Tabata RC, Garry RF, Shaw CA. ^ Adjuvants Pose Significant Toxicity Problem  Front Biosci.  Hauguel TM, Hackett CJ. ^ Glial Nerve Cell Inflammation in Autism  Ann Neurol.  Vargas DL, Nascimbene C, Krishnan C, Zimmerman AW, Pardo CA. ^ Manipulating NF-kappaB is Crucial in Better Vaccine Development  Proc Natl Acad Sci U S A.   Andreakos E, Williams RO, Wales J, Foxwell BM, Feldmann M. ^ Strategies for new Vaccines  Expert Rev Vaccines.  Wales J, Foxwell B, Feldmann M. ^ Brain Protection Against Methylmercury from Tocotrienols  Brain Res.  Shichiri M, Takanezawa Y, Uchida K, Tamai H, Arai H. ^ Tocotrienols Work In Part by Modulating NF-kappaB   J Biol Chem.   Ahn KS, Sethi G, Krishnan K, Aggarwal BB. ^ Tocotrienols for Brain Health  Ann N Y Acad Sci.  Sen CK, Khanna S, Roy S. ^ Tocotrienols Modulate NF-kappaB-Driven Circulatory Stress  Atherosclerosis  Theriault A, Chao JT, Gapor A. ^ Anti-Inflammatory Properties of Silymarin  J Immunol.   Manna SK, Mukhopadhyay A, Van NT, Aggarwal BB. ^ Silymarin Protects Your Brain from Excitotoxic Damage  Eur J Neurosci.   Wang MJ, Lin WW, Chen HL, Chang YH, Ou HC, Kuo JS, Hong JS, Jeng KC. ^ Silymarin Stops Nerve Damage  Arch Pharm Res.  Min K, Yoon WK, Kim SK, Kim BH. ^ Grape Seed Extracts Protect Against LPS-Induced Toxic Inflammation  : J Agric Food Chem.   Terra X, Valls J, Vitrac X, Mérrillon JM, Arola L, Ardèvol A, Bladé C, Fernandez-Larrea J, Pujadas G, Salvadó J, Blay M. ^ Grape Seed Extracts Protect Your Brain from Damage  J Agric Food Chem.  Guo L, Wang LH, Sun B, Yang JY, Zhao YQ, Dong YX, Spranger MI, Wu CF. ^ Grape Seed Extracts Protect Brain from Ongoing Damage  Pediatr Res.   Feng Y, Liu YM, Leblanc MH, Bhatt AJ, Rhodes PG. ^ Lipoic Acid and ALC Improve Brain Energy Function  J Cell Mol Med.   Aliev G, Liu J, Shenk JC, Fischbach K, Pacheco GJ, Chen SG, Obrenovich ME, Ward WF, Richardson AG, Smith MA, Gasimov E, Perry G, Ames BN. ^ Lipoic Acid Reduces Inflammation by Turning Down NF-kappaB  Int Immunopharmacol.  Lee CK, Lee EY, Kim YG, Mun SH, Moon HB, Yoo B. ^ Lipoic Acid stops LPS-Induced Inflammatory Toxicity  Proc Natl Acad Sci U S A.  Zhang WJ, Wei H, Hagen T, Frei B. ^ Acetyl-L-Carnitine Protects Nerves from Damage  Ann N Y Acad Sci.   Zanelli SA, Solenski NJ, Rosenthal RE, Fiskum G.

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